Description
CAS 1145998-81-7
For many years, researchers knew that complicated connections between the brain and the gonads controlled reproductive hormones, but they were unsure of the exact biochemical trigger. The identification of kisspeptin, a naturally occurring peptide encoded by the KISS1 gene that is essential for triggering the hypothalamic-pituitary-gonadal (HPG) axis, changed this. Gonadotropin-releasing hormone (GnRH) is released when kisspeptin, a short peptide, interacts to the GPR54 (KISS1R) receptor in the hypothalamus. Luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which are critical for the onset of puberty, fertility, and reproductive hormone balance, are secreted downstream as a result of this activity. Kisspeptin is regarded as a master regulator of reproductive endocrine function rather than a direct hormone replacement due to this strictly regulated signaling role (de Roux et al., 2003; Oakley et al., 2009).
References
de Roux, N., et al. (2003). Hypogonadotropic hypogonadism due to loss of function of the KISS1-derived peptide receptor GPR54. Proceedings of the National Academy of Sciences.
Oakley, A. E., et al. (2009). Kisspeptin signaling in the brain. Endocrine Reviews.
